Ovine TRIM5α can restrict visna/maedi virus.

نویسندگان

  • P Jáuregui
  • H Crespo
  • I Glaria
  • L Luján
  • A Contreras
  • S Rosati
  • D de Andrés
  • B Amorena
  • G J Towers
  • R Reina
چکیده

The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthesis, suggesting a conserved mechanism of restriction. Identification of TRIM5α active molecular species may open new prophylactic strategies against lentiviral infections.

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عنوان ژورنال:
  • Journal of virology

دوره 86 17  شماره 

صفحات  -

تاریخ انتشار 2012